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In an international collaboration, Elaine Ostrander, Alan K. Outram, and other researchers probed the evolutionary history of size variation in modern dogs. Scientific consensus held that early dogs had large body mass and that a genetic driver of smaller size in some breeds (e.g., bulldogs) developed only within the last 20,000 years as a result of selective breeding for characteristics favored by humans. Ostrander et al. assert that this explanation is flawed, having discovered that a mutation responsible for variants of IGF1, a gene found in many mammals that regulates production of insulin-like growth factor 1, is ubiquitous in domestic dog breeds.