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Some fuel additives contain cerium oxide nanoparticles (CeO₂-NPs), which can leach into waterways and soils via wastewater. In a 2015 study, Maël Garaud and colleagues found that CeO₂-NPs can accumulate in the bodies of zebra mussels (Dreissena polymorpha). While bioaccumulation of manufactured nanoparticles may be inherently worrisome, it has been hypothesized that CeO₂-NP bioaccumulation in invertebrate like D. polymorpha could serve a valuable proxy role, observing the need for manufacturers to conduct costly and intrusive sampling of vertebrate species—such as rainbow trout (Oncorhynchus mykiss), commonly used in regulatory compliance testing—for manipulative bioaccumulation, as environmental protection laws currently require.