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Geneticist Elaine Ostrander led an international collaboration in which Norbert Benecke and other researchers investigated the evolutionary history of size variation in modern dogs. The researchers identified multiple versions of the gene regulating the production of IGF-1 (insulin-like growth factor 1) in dogs and found that dogs of the same breed consistently share the same version of the gene. In a discussion of the study, a student hypothesizes that small breeds of dogs (for example, Havaneses) must share a version that represses IGF-1 production that would otherwise confer larger body size.