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According to historical documents, Marietta Strozzi—a young woman who was prominent in fifteenth-century Florentine culture—inspired several artworks, including a portrait bust sculpted by Desiderio da Settignano. Multiple sculptures dating to the period have been alleged to be the reported bust, but none have been authenticated as Desiderio's depiction of Strozzi. Given the historical importance of both Strozzi and Desiderio's sculpture of her, positively identifying the bust would be a notable accomplishment for art historians.

Although there is documentation that Desiderio was commissioned to sculpt the portrait bust of Strozzi, numerous instances of false identification have made art historians doubt that the sculpture will be discovered.

Although successfully finding and authenticating Desiderio's portrait bust of Strozzi is a challenge, the historical importance of the work justifies the continued pursuit of this goal.

Although numerous fifteenth-century Florentine portrait busts have been recovered over time, evidence has led art historians to conclude that Desiderio's bust of Strozzi is likely no longer extant.

Although historians strongly suspect that a particular sculpture is Desiderio's portrait bust of Strozzi, they do not currently have a method for conclusively verifying the artist or subject.