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Biologist Rosanna Alegado believes that we might learn how multicellular organisms developed from single-celled ones if we understand why the single-celled organism Salpingoeca rosetta, the oldest living relative of animals, sometimes forms colonies of cells. Alegado and colleagues reviewed data from many studies about how S. rosetta responds when exposed to another type of single-celled organism, bacteria, including Ingrid Brettar's work with Aquiflexum balticum bacteria and Jang-Cheon Cho's work with Croceibacter atlanticus bacteria. Alegado and colleagues concluded that neither A. balticum nor C. atlanticus are likely to have played a significant role in the development of multicellular organisms.