|Question 16Verbal

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Alfred Nobel intended for the Nobel Prize to be an award honoring those who have contributed "the greatest benefit to mankind." Indeed, the work of Richard Laurence Millington Synge represented a significant ____ the field of chemistry, and in 1952 he was among those awarded the Nobel Prize in Chemistry for "their invention of partition chromatography."
Which choice completes the text with the most logical and precise word or phrase?
controversy in
A
exposure to
B
dependence on
C
advancement in
D