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Biologist Rosanna Alegado believes that we might learn how multicellular organisms developed from single-celled ones if we understand why the single-celled organism Salpingoeca rosetta, the oldest living relative of animals, sometimes forms colonies of cells. Alegado and colleagues reviewed data from many studies of how S, rosetta responds when exposed to another type of single-celled organism, bacteria, including John P. Bowman's work with Algoriphagus ratkowskyi bacteria and Iftikhar Ahmed's work with Algoriphagus boritolerans bacteria. Alegado and colleagues concluded that both A, ratkowskyi and A, boritolerans might have played a role in the development of multicellular organisms.