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Michael G. Campana and colleagues relied on historical DNA (hDNA)—genomic data incidentally preserved in specimens housed in natural history collections—to investigate the evolutionary origins of a fungal pathogen affecting bats. Although this approach offers unique benefits, such as access to genomic data from extirpated populations, it remains a relatively underutilized resource because hDNA is often to some extent degraded, a situation not easily remediable under current methodological paradigms and with extant DNA extraction and analysis technologies.