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Some cosmetics contain silver nanoparticles (Ag-NPs), which can leach into waterways and soils via wastewater. In a 2014 study, Merel J.C. van der Ploeg and colleagues found that Ag-NPs can accumulate in the bodies of red earthworms (Lumbricus rubellus). While bioaccumulation of manufactured nanoparticles may be inherently worrisome, it has been hypothesized that Ag-NP bioaccumulation in invertebrates like L. rubellus could serve a valuable proxy role, obviating the need for manufacturers to conduct costly and intrusive sampling of vertebrate species-such as house mice (Mus musculus), commonly used in regulatory compliance testing—for nanoparticle bioaccumulation, as environmental protection laws currently require.