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Some toothpastes contain titanium dioxide nanoparticles (-NPs) which can leach into waterways and soils via wastewater. In a 2015 study, Adeline Bourgeault and colleagues found that -NPs can accumulate in the bodies of zebra mussels (Dreissena polymorpha). While bioaccumulation of manufactured nanoparticles may be inherently worrisome, it has been hypothesized that -NP bioaccumulation in invertebrates like D. polymorpha could serve a valuable proxy role, obviating the need for manufacturers to conduct costly and intrusive sampling of vertebrate species-such as common carp (Cyprinus carpio), commonly used in regulatory compliance testing-for nanoparticle bioaccumulation, as environmental protection laws currently require.